14-3-3 sigma (SFN)_珈得尔化学试剂

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14-3-3 sigma (SFN)

Rabbit Monoclonal Antibody

别名：	SFN antibody, YWHAS antibody, 14-3-3 protein sigma antibody, Epithelial cell marker protein 1 antibody, Stratifin antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177487	14-3-3 sigma (SFN)	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5872
【用途】WB
【抗原分子量】28kDa

质量标准：

【产品介绍】14-3-3 proteins are composed of a
highly conserved multigene family of small acidic
proteins. Responsive to DNA damage, 14-3-3 sigma
expression is induced in a p53-dependent manner.
14-3-3 sigma sequesters cyclin B1-CDC2 complex in
cytoplasm, and prevents its entry into nucleus resulting
in G2/M cell cycle arrest. Furthermore, 14-3-3 sigma
can link to CDK2 and CDK4 and block the cell cycle
entry. Thus, 14-3-3 sigma acts as a negative regulator
of cell cycle progression and is linked to cancer (1).
A keratinocyte-releasable form of 14-3-3 sigma is a
potent MMP-1-stimulatory factor in dermal fibroblasts.
When it is released from keratinocytes, it induces
the expression of MMP1, MMP3, MMP8 and MMP24 in
fibroblasts through the p38 mitogen-activated protein
kinase (MAPK) signaling pathway (2).

Recommended Applications

WB
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Western blot analysis on (A) fetal lung, (B) A549,
(C) human kidney, and (D) human spleen lysates
using anti-14-3-3 sigma RabMAb (cat. #5209-1).

Specificity

A synthetic peptide corresponding to residues in
human 14-3-3 sigma was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20 °C. Antibody buffer, 0.01% sodium azide,
50% Glycerol and 0.05% BSA. Stable for 12 months from
date of receipt