4-1BBL (TNFSF9)_珈得尔化学试剂

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4-1BBL (TNFSF9)

Rabbit Monoclonal Antibody

别名：	TNFSF9 antibody, 4-1BB-L antibody, CD137L antibody, Tumor necrosis factor ligand superfamily member 9 antibody, 4-1BB ligand antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177491	4-1BBL (TNFSF9)	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human
【克隆 ID】EPR1172Y
【用途】WB , IHC , ICC , IP
【抗原分子量】26kDa

质量标准：

【产品介绍】4-1BB was originally described as
a cDNA expressed by activated murine T cells
and subsequently demonstrated to encode a member
of the tumor necrosis factor receptor family of
integral membrane proteins. Recently, a murine ligand
for 4-1BB (mu4-1BB-L) was cloned and demonstrated to
be a member of an emerging family of ligands with
structural homology to tumor necrosis factor.
Both monoclonal antibody to hu4-1BB and cells
transfected with hu4-1BB-L induced a strong
proliferative response in mitogen co-stimulated
primary T cells. In contrast, ligation of 4-1BB
on T cell clones enhanced activation-induced cell
death when triggered by engagement of the TCR/CD3
complex. (1). To reject tumors, T cells must overcome
poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary
human T cells expressing CD80 and 4-1BBL vigorously
respond to tumor cells lacking costimulatory ligands
and provoke potent rejection of large, systemic tumors
in immunodeficient mice (2).

Recommended Applications

WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:500
IHC: 1:100
ICC: 1:100
IP: 1:40
Species Reactivity *

Human

*Cross reactivity determined by western blot only.

Specificity

A synthetic peptide corresponding to residues near
the N-terminus of human 4-1BBL was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.