ACO1_珈得尔化学试剂

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ACO1

Rabbit Monoclonal Antibody

别名：	ACO1 antibody, ACONS antibody, IREB1 antibody, IREBP antibody, IREBP1 antibody, IRP1 antibody, Cytoplasmic aconitate hydratase antibody, Iron-responsive element-binding protein 1 antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177505	ACO1	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR7225
【用途】WB , ICC , IP
【抗原分子量】98kDa

质量标准：

【产品介绍】Aconitase 1, also known as iron
regulatory element binding protein 1 (IREB1) or ACO1,
is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in
the 5' UTR of ferritin mRNA, and in the 3' UTR
of transferrin receptor mRNA. The iron-induced binding
to the IRE results in repression of translation of
ferritin mRNA, and inhibition of degradation of
the otherwise rapidly degrading transferrin receptor
mRNA. Thus, IREB1 plays a central role in cellular
iron homeostasis. ACO1 was also shown to have
aconitase activity, and hence grouped with the
aconitase family of enzymes (1).

Recommended Applications

WB, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:100 - 250
IP: 1:10 - 100
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data
Western blot analysis on (A) human thyroid, (B) HeLa,
(C) fetal kidney, (D) HepG2, and (E) T.T. lysates
using anti-ACO1 RabMAb (cat. #5505-1).
Immunofluorescent staining of HeLa cells using
anti-ACO1 RabMAb (cat. #5505-1).

Specificity

A synthetic peptide corresponding to residues in human
ACO1 was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20° C. Buffer: Antibody buffer, sodium
azide, glycerol, and BSA. Stable for 12 months from date
of receipt.