Ape 1 (APEX1)_珈得尔化学试剂

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Ape 1 (APEX1)

Rabbit Monoclonal Antibody

别名：	APEX1 antibody, APE antibody, APE1 antibody, APEN antibody, APEX antibody, APX antibody, HAP1 antibody, REF1 antibody, DNA-(apurinic or apyrimidinic site) lyase, mitochondrial antibody, REF-1 antibody, Redox factor-1 antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177533	Ape 1 (APEX1)	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR4022
【用途】WB , IHC
【抗原分子量】36kDa

质量标准：

【产品介绍】Apurinic endonuclease (Ape 1) functions as
a major DNA repair enzyme that is essential
for embryogenesis and cell viability (1). It is involved
in the base excision repair (BER) pathway and acts as
a reduction-oxidation signaling factor to
maintain transcription factors in an active reduced
state (2). Ape 1 plays a critical role as a
transcriptional coactivator for different
transcription factors (i.e. AP-1, NF-kappaB, p53)
in controlling different cellular processes such
as apoptosis, proliferation, and differentiation
(3). Elevated levels of Ape 1 have been found in
cancers such as ovarian, cervical, and prostate (4).

Recommended Applications

WB, IHC
Applications and Recommended Dilution Factors

WB: 1:10,000-50,000
IHC: 1 : 100 - 250
Species Reactivity *

Human, Mouse, Rat

*Mouse cross reactivity tested by western blot and
IHC Rat cross reactivity tested by western blot only

Products Data
Western blot analysis on (A) K562, (B) HepG2, and (C)
Raji cell lysates using anti-Ape 1 RabMAb (cat. #2851-1).

Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-Ape 1 RabMAb (cat. #2851-1).

Immunohistochemical analysis of paraffin-embedded
human kidney tissue using anti-Ape 1RabMAb (cat. #2851-1).

Specificity

A synthetic peptide corresponding to residues near
the N-terminus in human Ape 1 was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.