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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177570 | Beta Tubulin class III (C-term) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP1569Y 【用途】WB , IHC , ICC , FC , IP 【抗原分子量】55 kDa |
| 质量标准： | 【产品介绍】Microtubules are essential parts in eukaryotic cell structures, transp o r tation, a n d mitosis a n d consists mainly of 2 soluble protein subunits, alpha a n d beta tubulin. Beta-tubulin binds to alpha tubulin to f o r m tubulin heterodimer which is post-translationally modified (1). The tubulin dimer complex binds to GTP a n d assembles onto the positive ends of microtubules. After inc o r p o r ation into the microtubules, bound GTP is hydrolyzed by beta tubulin. The stability of the dimer in the microtubules is depended on presence of beta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubule inc o r p o r ation (2). Class III beta tubulin (beta III-tubulin) is a vertebrate tubulin Isotype specific to the neurons a n d mammalian testis cells, making it an ideal neuronal marker. Overexpression of class III beta tubulin is associated with the resistances of microtubule-targeted cancer drugs in lung cancer cell lines, breast cancer cell lines, a n d ovarian tum o r s (3).
A. Western blot analysis on HeLa cell lysate using B. Immunohistochemical analysis of paraffin-embedded |
