CHAF1A_珈得尔化学试剂

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CHAF1A

Rabbit Monoclonal Antibody

别名：	CHAF1A antibody, CAF-1 antibody, CAF1 antibody, CAF1B antibody, CAF1P150 antibody, MGC71229 antibody, P150 antibody, Chromatin assembly factor 1 subunit A antibody, Chromatin assembly factor I p150 subunit antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177648	CHAF1A	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human
【克隆 ID】EPR5576(2)
【用途】WB , IHC , ICC , FC , IP
【抗原分子量】150kDa

质量标准：

【产品介绍】Chromatin assembly factor I (CAF1) is a
nuclear complex consisting of p50, p60, and p150
(CHAF1A) subunits (1). CHAF1A regulates the formation
of heterochromatin in mammalian cells during
replication. This subunit exists in a
chromatin-remodeling complex WINAC, which coactivates
ligand-induced transactivation function of the vitamin
D receptor (2). As a histone chaperone, the CAF1
complex deposits histones H3/H4 onto DNA in a
replication-dependent manner. CAF1 is required for
cell proliferation and early development in
animals. Proliferating cell nuclear antigen (PCNA) and
CAF1 association has also been linked to DNA repair,
in particular nucleotide excision repair, and to
major mechanisms of double strand break (DSB) repair,
such as homologous recombination (HR) and nonhomologous
end joining (3). Furthermore, CAF1 is involved in
the regulation of cell differentiation and cell
cycle duration (3).

Recommended Applications

WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) Jurkat, (B) HeLa treated
with Hydroxyurea, (C) HeLa, and (D) K562 cell lysates
using anti-CHAF1A RabMAb (cat. #5464-1).

Immunohistochemical analysis of paraffin-embedded
human colon tissue using anti-CHAF1A RabMAb (cat. #5464-1).

Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-CHAF1A RabMAb (cat. #5464-1).

Specificity

A synthetic peptide corresponding to residues in
human CHAF1A was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20° C. Buffer: Antibody buffer, sodium
azide, glycerol, and BSA. Stable for 12 months from date
of receipt.