4007787550
|
 |
||||||||||||||
| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177651 | Chk2 (CHEK2) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human 【克隆 ID】EPR5528 【用途】WB 【抗原分子量】62kDa |
| 质量标准： | 【产品介绍】Chk2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, Chk2 is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in Chk2 have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this protein are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors (1).
WB WB: 1:10,000 - 50,000 Human *Cross reactivity determined by western blot only. Products Data Western blot analysis on (A) SH-SY5Y, (B) HeLa, Specificity A synthetic peptide corresponding to residues at |
| 贮存： | Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), |
