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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177700 | DAPK2 (N-term) | -- | 100g | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP1633Y 【用途】WB , IHC , FC 【抗原分子量】43 kDa |
| 质量标准： | 【产品介绍】Protein kinase termed death-associated protein kinase 2 (DAPK2) dependant on calcium/ calmodulin (Ca2+/CaM) contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant homologies to those of DAP kinase, a protein kinase involved in apoptosis. Overexpression of DAPK2 significantly induced the m o r phological changes characteristic of apoptosis. Results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling (1). The region of homology spans the catalytic domain a n d the CaM-regulat o r y region, whereas the remaining C-terminal part of the protein differs completely from DAP kinase a n d displays no homology to any known protein. The catalytic domain is also homologous to the recently identified ZIP kinase a n d to a lesser extent to the catalytic domains of DRAK1 a n d -2 (2). DAPK2 has a novel regulat o r y mechanism that controls its pro-apoptotic functions. It comprises a single autophosph o r ylation event mapped to Ser308 within the CaM regulat o r y domain. A negative charge at this site reduces both the binding to CaM a n d the f o r mation of DRP-1 homodimers (3).
B. Immunohistochemical staining of paraffin-embedded |
