4007787550
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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177742 | EGFR | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】E114 【用途】WB , IHC , ICC , IP 【抗原分子量】170-180 kDa |
| 质量标准： | 【产品介绍】Epidermal growth fact o r recept o r (EGFR) is a 170 kDa transmembrane glycoprotein recept o r tyrosine kinase that, activated by epidermal growth fact o r (EGF), affects cell growth a n d differentiation (1). Binding of EGF o r TGF alpha to EGFR activates tyrosine kinase activity of the recept o r (2). Phosph o r ylation of Tyr 992, Tyr 1068 a n d Tyr 1086 is required f o r conf o r mational change in the C-terminal of EGFR (3). Autophosph o r ylation of Tyr 992 c r e a t e s a binding site f o r the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling (4).
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