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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177743 | EGFR (C-term) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human 【克隆 ID】E235 【用途】WB , ICC , FC , IP 【抗原分子量】170 kDa |
| 质量标准： | 【产品介绍】Epidermal growth fact o r recept o r (EGFR) is a 170 kDa transmembrane glycoprotein recept o r tyrosine kinase that, activated by epidermal growth fact o r (EGF), affects cell growth a n d differentiation (1). Binding of EGF o r TGF alpha to EGFR activates tyrosine kinase activity of the recept o r (2). The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, a n d Tyr 1173, are the maj o r sites of autophosph o r ylation, which occurs as a result of EGF binding (3). Once activated, EGFR phosphotyrosines Y-1068 a n d Y-1173 mediate the binding of Grb2 to the EGFR. Another autophosph o r ylation site, Tyr 1086, is situated within the cytoplasmic domain, a n d is phosph o r ylated to a higher extent by c-Src than by EGFR (4).
B. Immunoflu o r escent staining of A431 cells |
