EphA3 Phospho (pY779) / EphA4 (pY779) / EphA5 (pY833) (EPHA3)

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EphA3 Phospho (pY779) / EphA4 (pY779) / EphA5 (pY833) (EPHA3)

Rabbit Monoclonal Antibody

别名：	EPHA3 antibody, EK4 antibody, ETK antibody, ETK1 antibody, HEK antibody, HEK4 antibody, TYRO4 antibody, Ephrin type-A receptor 3 antibody, HEK antibody, Tyrosine-protein kinase TYRO4 antibody, Tyrosine-protein kinase receptor ETK1 antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177757	EphA3 Phospho (pY779)	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5684
【用途】WB
【抗原分子量】133kDa

质量标准：

【产品介绍】Ephrin receptor tyrosine kinases (RTKs)
and their ligands (ephrins) are highly conserved
families that mediate cell movement during development
(1). There are 14 known receptors, classed into either
EphA or EphB, and 8 known ligands, classed into ephrin A
or ephrin B. EphA receptors preferably interacts
with glycosylphosphatidylinositol-linked ephrins
(ephrin A), while EphB receptors preferably interacts
with transmembrane ligands (ephrin B) (2). Multiple
ligands are specific to each Ephrin receptors and
cause receptor activation through transphosphorylation
(3, 4). Both receptor and ligand-initiated signals
can regulate repulsion, adhesion and de-adhesion
mechanisms for the motility of adherent cells (5). Ephrin
A3 (EphA3, Mek4, Hek, Hek4) binds to ephrin-A1 to A5
and ephrin-B1. A mutation in EphA3 has been linked
to pathogenesis in several tumors, such as breast, lung,
and pancreatic cancers (6). Tyrosine 779 of EphA3
is phosphorylated and required to mediate cell
de-adhesion upon ephrin-A5 stimulation (7).

Recommended Applications

WB
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on HeLa cell lysates
using anti-Phospho-EphA3 (pY779) / EphA4 (pY779) /
EphA5 (pY833) RabMAb (cat. #5252-1). Cells were
either (A) untreated or (B) treated with Pervanadate.

Specificity

A phospho specific peptide corresponding to
residues surrounding Tyrosine 779 of human EphA3,
Tyrosine 779 of EphA4, and Tyrosine 833 of EphA5 was used
as an immunogen. This antibody only detects
EphA3 phosphorylated at Tyrosine 779, EphA4
phosphorylated at Tyrosine 779, and EphA5 phosphorylated
at Tyrosine 833.

贮存：

Storage Condition and Buffer

Store at -20 °C. Antibody buffer, 0.01% sodium azide,
50% Glycerol and 0.05% BSA. Stable for 12 months from date
of receipt