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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177780 | FAK Phospho (pY576) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP1987Y 【用途】WB , FC 【抗原分子量】125 kDa |
| 质量标准： | 【产品介绍】Focal adhesion kinase (FAK) is a non-recept o r protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation a n d apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- a n d C-terminal regions. FAK is activated by phosph o r ylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion o r antibody cross-linking o r via G-protein-coupled recept o r (GPCR) occupancy by lig a n d s such as bombesin o r lysophosphatidic acid (2-3). Phosph o r ylation of FAK Tyr-397 c r e a t e s a binding site f o r Src-family kinases, a n d phosph o r ylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity (4). Increased FAK expression has been c o r related with the enhanced motility a n d invasiveness of human tum o r cells, as well as with promoting increased cell proliferation (5).
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