Fibrinogen gamma chain (FGG)_珈得尔化学试剂

【产品介绍】Fibrinogen is comprised of two sets of
three polypeptide chains termed alpha, beta and gamma
that are joined by disulfide bridging within the
N-terminal E domain (1). Following vascular
injury, fibrinogen is cleaved by thrombin to form
fibrin which is the most abundant component of blood
clots. Fibrinogen binds through its gamma chain to
cell surface receptors, growth factors, and
coagulation factors to perform key roles in fibrin
clot formation, platelet aggregation, and wound
healing (2). Fibrinogen gamma chain, a
fibrinogen gamma-chain variant generated via
alternative mRNA processing, binding to thrombin and
factor VIII results in clots that are mechanically
stiffer and resistant to fibrinolysis (2). Elevated
plasma fibrinogen gamma concentration is associated
with myocardial infarction (3). Fibrinogen-gamma
C-terminal fragments can induce endothelial
barrier dysfunction and microvascular leak (4).

Recommended Applications

WB, IHC
Applications and Recommended Dilution Factors

WB: 1:500 - 1,000
IHC: 1:100 - 250
Species Reactivity

Human

Products Data

Western blot analysis on human plasma lysates
using anti-Fibrinogen gamma chain RabMAb (cat. #2743-1).

Immunohistochemical analysis of paraffin-embedded
human liver tissue using anti-Fibrinogen gamma chain
RabMAb (cat. #2743-1).

Specificity

A synthetic peptide corresponding to residues in
human Fibrinogen gamma chain was used as an immunogen.

贮存：

Storage Condition and Buffer

Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.