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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177829 | GCN2 (EIF2AK4) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human 【克隆 ID】EPR5970(2) 【用途】WB , IHC , ICC , FC 【抗原分子量】220kDa |
| 质量标准： | 【产品介绍】In eukaryotic cells, protein synthesis is regulated in response to various environmental stresses by phosphorylating the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha). Four different eIF2alpha kinases have been identified in mammalian cells, the heme-regulated inhibitor (HRI), the interferon-inducible RNA-dependent kinase (PKR) and the endoplasmic reticulum-resident kinase (PERK) and GCN2, which was previously characterized from Saccharomyces cerevisiae, Drosophila melanogaster and Neurospora crassa. GCN2 is the unique eIF2alpha kinase present in all eukaryotes from yeast to mammals (1). GCN2, a sensor of amino acid deficiency, plays a key role in yeast and mammals in modulating amino acid metabolism as part of adaptation to nutrient deprivation. (2). Results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2alpha phosphorylation and cyclin D1 translation after unfolded protein response pathway activation (3).
WB, IHC, ICC, FC WB: 1:1,000 - 10,000 Human *Species cross-reactivity is based on WB analysis. Products Data Immunohistochemical analysis of paraffin-embedded Specificity A synthetic peptide corresponding to residues near |
| 贮存： | Storage Condition and Buffer Store at -20° C. Buffer: PBS (pH 7.2), 0.01% sodium |
