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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227178913 | Alpha-Actinin 3 | -- | 100ul | 1716元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR2532 【用途】WB 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】100 kDa |
| 质量标准： | 【产品介绍】The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin, ACTN2 and ACTN3, are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibers, while ACTN3 expression is restricted to a subset of type 2 fibers. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype, raising the possibility that ACTN3 is functionally redundant in humans, and that alpha-actinin-2 is able to compensate for alpha-actinin-3 deficiency (1). Alpha-Actinin-3 is specifically expressed in fast-twitch myofibers responsible for generating force at high velocity. The absence of a disease phenotype secondary to alpha-actinin-3 deficiency is likely due to compensation by the homologous protein, alpha-actinin-2. However, the high degree of evolutionary conservation of ACTN3 suggests function(s) independent of ACTN2. Highly significant associations between ACTN3 genotype and athletic performance have been demonstrated in both male and female athletes. Recommended Applications Species Reactivity* Western blot analysis on (A) human skeletal muscle, Specificity |
| 贮存： | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
