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货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
JD1227178942 | HIAP-1/BIR3 | -- | 100ul | 0元 | 现货 | 3天 |
性状: | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human , Rat 【克隆 ID】E40 【用途】WB , IHC , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】72 kDa |
质量标准: | 【产品介绍】cIAP-2, also known as HIAP-1, is a member of the inhibit o r of apoptosis (IAP) family of proteins. These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus (1). cIAP-2 is localized to the cytoplasm. The BIR motifs region interacts with TNF recept o r associated fact o r s 1 a n d 2 (TRAF1 a n d TRAF2) to f o r m a heteromeric complex, which is then recruited to the tum o r necrosis fact o r recept o r 2 (TNFR2). This complex is thought to play a role in inhibition of apoptosis (2,3). cIAP-2 inhibits cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade a n d apoptosis (4). WB: 1:500 A. Western blot analysis on Daudi cell lysate B. Immunohistochemical analysis of human n o r mal |