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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227178967 | HSD17B1 (C-term) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal Antibody 【反应特异性】Human 【克隆 ID】EP1681Y 【用途】WB , IHC , ICC , FC 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】35kDa |
| 质量标准： | 【产品介绍】The principal human estrogen, 17 beta- estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4) Recommended Applications Products Data A. Western blot analysis on human placenta lysate Immunohistochemical analysis of paraffin-embedded Specificity |
| 贮存： | Store at -20 °C. 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
