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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179006 | IRS-1 Phospho (pY896) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP260Y 【用途】WB 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】170 kDa |
| 质量标准： | 【产品介绍】Insulin recept o r substrates (IRS), the maj o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulat o r s of IR a n d the insulin-like growth fact o r -1 recept o r . Disruption of IRS-1 causes growth retardation a n d insulin resistance associated with hypertension, hypertriglyceridemia, a n d impaired endothelium-dependent vascular relaxation (4-5) WB: 1:500,000 A. Western blot analysis on 293 cell lysates |
