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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179009 | JAK2 | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal Antibody 【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR108(2) 【用途】WB , ICC 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】130kDa |
| 质量标准： | 【产品介绍】JAK2 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction (1). The JAK family is constitutively associated with cytokine receptors; upon ligand binding, JAK phosphorylates the receptor. JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1, 3). JAK2 is activated after binding to the following Interleukin receptors: specifically IL-3 and IL-23 (4). It also plays a role in leptin signaling and control of body weight (4). A chromosomal aberration involving JAK2 is found in a form of pre-B acute myeloid leukemia (5). Recommended Applications Western blot analysis on (A) TF-1, (B) K562, (C) THP-1, Specificity |
| 贮存： | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
