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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179011 | JAK3 | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Polyclonal IgG Affinity Purified 【反应特异性】Human , Rat 【克隆 ID】Polyclonal 【用途】WB 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】115 kDa |
| 质量标准： | 【产品介绍】Jak3 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines a n d interferons. Jaks associate with cytokine recept o r s; upon lig a n d binding, Jaks phosph o r ylate the recept o r . The phosph o r ylated recept o r s are bound by SH2-containing proteins, one class of which is the signal transducers a n d activat o r s of transcription (STATs). Activated STATs translocate to the nucleus to mediate gene transcription (1, 2). Jak3 is activated after binding to the gamma chain of Interleukin recept o r s, specifically IL-2, IL-4, IL-7, IL-9, a n d IL-15 recept o r s. Jak3 has been implicated in mast cell-mediated immediate hypersensitivity reactions, autoimmune dis o r ders, a n d acute lymphoblastic leukemia. Jak3 inhibit o r has shown clinical potential as a new class of immunomodulat o r y agents with anti-leukemic a n d immunosuppressive properties (3). WB: 1:2000 A. Western blot using anti-Jak3 Rabbit Polyclonal |
