JAK3_珈得尔化学试剂

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JAK3

别名：	JAK3 antibody, JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, Tyrosine-protein kinase JAK3 antibody, Leukocyte janus kinase antibody
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227179013	JAK3	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR908(2)
【用途】WB , ICC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】115kDa

质量标准：

【产品介绍】JAK3 is a member of the Janus family
(JAK) tyrosine kinases involved in cytokine
receptor-mediated intracellular signal transduction. The
JAK family is constitutively associated with
cytokine receptors; upon binding to the receptor,
the cytokine becomes phosphorylated (1). JAK
also phosphorylates the cytokine receptor on tyrosine
(Tyr) residues that serve as docking sites for
cytoplasmic signal transducers and activators
of transcription (STAT) proteins (2). Activated
STATs translocate to the nucleus to mediate
gene transcription (1). JAK3 is unique among JAK
family members because it serves a function in
normal lymphocyte development. In addition, JAK3 is the
only one that interacts with the common gamma chain of
the following Interleukin receptors: IL-2, IL-4, IL-7,
IL-9, and IL-15 receptors (3). Loss of JAK3 function
causes a severe block in T-cell and natural killer (NK)
cell development (4). Defects in JAK3 are a cause of
severe combined immunodeficiency (SCID), characterized by
an absence of T-cell-mediated cellular immunity (5).

Recommended Applications
WB, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000-10,000
ICC: 1:250 - 500
Species Reactivity
Human
Products Data

Western blot analysis on (A) IM-9 and (B) TF-1 cell
lysates using anti-JAK3 RabMAb (cat. # 2856-1).

Specificity
A synthetic peptide corresponding to residues on
the N-terminus in human JAK3 was used as an immunogen.

贮存：

Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.