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货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
JD1227179030 | Kv4.2 | -- | 100ul | 0元 | 现货 | 3天 |
性状: | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human 【克隆 ID】EP982Y 【用途】WB , IHC , FC 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】80 kDa |
质量标准: | 【产品介绍】Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) rec o r ded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the p o r e-f o r ming alpha-subunits of the Kv4.x family, are particularly imp o r tant in regulating membrane excitability in the CNS a n d the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current a n d is localized to dendrites a n d cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene a n d a loss of Kv4.2 protein resulted in a specific a n d near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude a n d an increase of concurrent Ca2+ influx (3). WB: 1:1000 A. Western blot analysis on human brain lysate B. Immunohistochemical staining of paraffin-embedded |