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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179033 | LAT Rabbit Antibody | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】 【克隆 ID】Y109 【用途】WB , IHC , FC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】36/38 kDa |
| 质量标准： | 【产品介绍】LAT (linker f o r activation of T-cells) is involved in the T-cell antigen recept o r (TCR) signal transduction pathway, a n d may play an imp o r tant role downstream in activating protein tyrosine kinases (1). LAT is phosph o r ylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 a n d Tyr171 are required f o r T-cell activation a n d Tyr132 is required f o r the activation of PLCgamma1 a n d Ras signaling pathways, respectively. Tyr226 a n d Tyr191 are required f o r Vav binding, whereas Tyr171 a n d Tyr132 are necessary f o r association a n d activation of phosphoinositide 3-kinase activity a n d PLCgamma1 (3). WB: 1:500 A. Western blot analysis on Jurkat cell lysate B. Immunohistochemical analysis of paraffin-embedded |
