LFA-1a (ITGAL)/CD11a_珈得尔化学试剂

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LFA-1a (ITGAL)/CD11a

别名：	Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a antigen
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227179037	LFA-1a (ITGAL)/CD11a	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human
【克隆 ID】EP1285Y
【用途】WB , IHC , ICC , FC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】180 kDa

质量标准：

【产品介绍】In the immune system, integrins have
essential roles in leukocyte trafficking a n d
function. These include immune cell attachment
to endothelial a n d antigen-presenting cells,
cytotoxicity, a n d extravasation into tissues (1).
Integrin adhesion recept o r s transduce signals
that control complex cell functions which require
the regulation of gene expression, such as
proliferation, differentiation a n d survival.
Their intracellular domain has no catalytic
function, indicating that interaction with other
transducing molecules is crucial f o r integrin-
mediated signaling. JAB1 (Jun activation domain-
binding protein 1), a coactivat o r of the
c-Jun transcription fact o r , has been identified as
a protein that interacts with the cytoplasmic domain of
the beta2 subunit of the alphaL/beta2 integrin LFA-1
(2). Patients with leukocyte adhesion molecule
(CD11/CD18, beta 2 integrins) deficiency have
structural defects in the common beta subunit (CD18),
which prevent heterodimer f o r mation a n d n o r mal
cell surface expression of these recept o r s, leading
to life-threatening bacterial infections (3)

WB: 1:20,000
IHC: 1:100 250
ICC: 1:100 250
Flow Cytometry: 1:80
IP: 1:100

A. Western blot analysis on Jurkat cell lysate
using anti-LFA-1a RabMAb (cat. # 1904-1), dilution 1:20,000.

B. Immunohistochemical staining of paraffin-embedded
human spleen using anti-LFA-1a RabMAb (cat. #1904-1).