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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179039 | LFA-β2/ITGB2 | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human 【克隆 ID】EP1286Y 【用途】WB , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】95 kDa |
| 质量标准： | 【产品介绍】In the immune system, integrins have essential roles in leukocyte trafficking a n d function. These include immune cell attachment to endothelial a n d antigen-presenting cells, cytotoxicity, a n d extravasation into tissues (1). Integrin adhesion recept o r s transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation a n d survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial f o r integrin- mediated signaling. JAB1 (Jun activation domain- binding protein 1), a coactivat o r of the c-Jun transcription fact o r , has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer f o r mation a n d n o r mal cell surface expression of these recept o r s, leading to life-threatening bacterial infections (3) WB: 1:2000 A. Western blot analysis on K562 cell lysate |
