Recombinant Human Bone Morphogenetic Protein 4 是一种有效的骨形成蛋白，同时为转化生长因子 (TGF-β)超家族的一部分，在间质细胞形成和多个器官的发育过程中起作用。
Synonyms
rHuBMP-4; BMP-2B ; 重组人骨形态发生蛋白 4
Species
HumanSource
E. coli Accession
P12644 Gene ID
652 Molecular Weight
Approximately 13.3 kDa AA Sequence
MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against solution in 50 mM Na2CO3, 5 mM DTT, pH 11.0. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Bone Morphogenetic Protein 4 (rHuBMP-4) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Bone Morphogenetic Protein 4 (rHuBMP-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Bone morphogenetic protein-4 (BMP-4) is a member of the BMP-family, a group of growth factors, initially discovered for their ability to initiate bone formation when transplanted to ectopic sites. Bone morphogenetic protein-4 is part of the transforming growth factor (TGF-β) superfamily and is widely expressed from early embryogenesis through adulthood. Bone morphogenetic protein-4 also plays a key role in mesenchyme formation and the development of multiple organs. In addition, BMP-4 also functions as a differentiation factor to hematopoietic and nerve cells and promotes epidermal commitment. Mature BMP-4 is a homodimeric glycoprotein with a cystine knot[1]. |
