Recombinant Human Endostatin (P.pastoris-expressed) 是一种内源性抗血管新生肽，在细胞质中能够通过调节多种受体来抗肿瘤，例如，抑制血管新生，抑制肿瘤细胞的迁移和入侵。
Synonyms
rHuEndostatin; Collagen alpha-1(XV) chain ; 重组人血管内皮抑制素 (P.pastoris 表达)
Species
HumanSource
P. pastoris Accession
P39060 Gene ID
80781 Molecular Weight
Approximately 16 kDa AA Sequence
AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK Biological Activity
The ED50 is 10μg/mL as measured by Endothelial cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 17 mM citric-phosphate buffer, pH 6.2. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Endostatin (P.pastoris-expressed) (rHuEndostatin) to 100 µg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Endostatin (P.pastoris-expressed) (rHuEndostatin) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Endostatin is an endogenous antiangiogenic peptide with multiple antitumor roles through modulation of various receptors in the plasma membrane, such as suppression of angiogenesis and inhibition of tumor-cell migration and invasion[1]. Recombinant Human Endostatin (rhEndostatin) shows a potent bioactivity and is capable of synergizing with CTX and DDP in suppression of tumor cell growth[2]. |
