Recombinant Human Epigen 是一种表皮生长因子，对只表达 ErbB-2 的细胞没有刺激作用，在表达 ErbB-1， 共表达 ErbB-2 和其他 ErbB 的细胞中，作为细胞分裂素能够促进细胞有丝分裂。
Synonyms
rHuEpigen; Epithelial mitogen; EPG ; 重组人 Epigen 因子
Species
HumanSource
E. coli Accession
Q6UW88 Gene ID
255324 Molecular Weight
Approximately 8.1 kDa AA Sequence
MAVTVTPPIT AQQADNIEGP IALKFSHLCL EDHNSYCING ACAFHHELEK AICRCFTGYT GERCEHLTLT SYA Biological Activity
The ED50 is <1 μg/mL as measured by 3T3 cells, corresponding to a specific activity of >1 × 103 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Epigen (rHuEpigen) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Epigen (rHuEpigen) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Epigen is a EGF-like growth factor that does not stimulate cells singly expressing ErbB-2, but acts as a mitogen for cells expressing ErbB-1 and co-expressing ErbB-2 in combination with the other ErbBs, with potent mitogenic activity[1]. |
