Recombinant Human Interferon-alpha2b 是为 I 型干扰素，具有免疫调节作用，可抗病毒、抗肿瘤。
Synonyms
rHuIFN-α2b; IFNA; INFA2; IFN-a 2b ; 重组人干扰素-α2b
Species
HumanSource
E. coli Accession
P01563 Gene ID
3440 Molecular Weight
Approximately 19.2 kDa AA Sequence
CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Biological Activity
The ED50 is <0.05 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >2.0 × 107 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interferon-alpha2b (rHuIFN-α2b) to 100 µg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Interferon-alpha2b (rHuIFN-α2b) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human Interferon-α is a cytokine belonging to the type I Interferons (IFNs), acts as a regulatory mediator of the immune response, and also shows antiviral, antitumor activity. IFNsα are used in treatment of hepatitis B and C and in antitumor therapy[1]. Human Interferon-α2 can also be used to treat hairy cell leukemia, chronic myelogenous leukemia, malignant melanoma, follicular lymphoma, condylomata acuminata, and AIDS-related Kaposi sarcoma[2]. |
