combinant Human Keratinocyte Growth Factor 1/FGF-7 是一种多肽有丝分裂原，属于成纤维细胞生长因子家族，只与 FGFR2 的拼接变体 FGFR2 IIIb 结合，为上皮细胞特异性的旁泌生长因子，与其受体在创口愈合过程中起到重要作用。
Synonyms
rHuKGF-1/FGF-7; Keratinocyte Growth Factor; Fibroblast Growth Factor-7; HBGF-7 ; 重组人角质细胞生长因子 1/FGF-7
Species
HumanSource
E. coli Accession
P21781 Gene ID
2252 Molecular Weight
Approximately 19.0 kDa AA Sequence
MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT Biological Activity
The ED50 is <2 ng/mL as measured by 4MBr-5 cells, corresponding to a specific activity of >5.0 × 105 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Keratinocyte Growth Factor 1/FGF-7 (rHuKGF-1/FGF-7) to 100 µg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Keratinocyte Growth Factor 1/FGF-7 (rHuKGF-1/FGF-7) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Keratinocyte growth factor 1 or FGF-7 is a polypeptide mitogen that belongs to the family of fibroblast growth factors, binds only to a splice variant of FGFR2 (FGFR2 IIIb) and is a highly specific paracrine growth factor for epithelial cells. FGF-7 and its receptor are believed to be important for normal wound healing[1]. |
