Recombinant Human BCMA 是肿瘤坏死因子 (TNF) 受体家族成员之一，能够促进 B 细胞的存活，在体液免疫中发挥重要作用。
Synonyms
rHuBCMA; TNFRSF17; CD269; B-cell maturation protein; BCM ; 重组人B细胞成熟蛋白
Species
HumanSource
E. coli Accession
Q02223 Gene ID
608 Molecular Weight
Approximately 5.4 kDa AA Sequence
AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA Biological Activity
The ED50 is <40 ng/mL as measured by murine B cells, corresponding to a specific activity of >2.5 × 104 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 30% acetonitrile, 0.1% TFA. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human BCMA (rHuBCMA) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human BCMA (rHuBCMA) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
BCMA, a member of tumor necrosis factor receptor superfamily, could promote B-cell survival and plays a role in the regulation of humoral immunity[1]. BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment. BCMA plays an important role in B-cell development, function and regulation. BCMA also has the capability to activate NF-κB and JNK[2]. |
