Recombinant Human Cardiotrophin-1 (CHO-expressed) 是IL-6细胞因子家族的一员，是能量稳态和糖脂代谢的关键调控因子。
Synonyms
rHuCT-1; CTF1 ; 重组人Cardiotrophin-1 (CHO细胞表达)
Species
HumanSource
CHO Accession
Q16619 Gene ID
1489 Molecular Weight
24-26 kDa AA Sequence
SRREGSLEDP QTDSSVSLLP HLEAKIRQTH SLAHLLTKYA EQLLQEYVQL QGDPFGLPSF SPPRLPVAGL SAPAPSHAGL PVHERLRLDA AALAALPPLL DAVCRRQAEL NPRAPRLLRR LEDAARQARA LGAAVEALLA ALGAANRGPR AEPPAATASA ASATGVFPAK VLGLRVCGLY REWLSRTEGD LGQLLPGGSA Biological Activity
The ED50 is <0.4 ng/mL as measured by TF-1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Cardiotrophin-1 (CHO-expressed) (rHuCT-1) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Cardiotrophin-1 (CHO-expressed) (rHuCT-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Cardiotrophin (CT)-1 belongs to the IL-6 family of cytokines[1]. Cardiotrophin-1 (CT1) plays an important role in the differentiation, development, and survival of neural stem cells. CT1 plays a key role in neural tissue development and has survival-promoting, anti-apoptotic effects in neural injury or death. CT1 induces a phenotypic switch in sympathetic neurons and promotes the survival of dopaminergic neurons from the central nervous system and ciliary neurons from the periphery[2]. |
