Recombinant Human Interleukin-2 Receptor alpha, His (HEK293-expressed)，也称为Tac抗原和CD25，是42kDa的跨膜蛋白。 Interleukin-2受体α，β和γ链构成高亲和力IL2受体
Synonyms
rHuIL-2Rα, His; TAC-antigen; CD25
Species
HumanSource
HEK 293 Accession
P01589 Gene ID
3559 Molecular Weight
Approximately 42 kDa AA Sequence
HHHHHHHHEL CDDDPPEIPH ATFKAMAYKE GTMLNCECKR GFRRIKSGSL YMLCTGNSSH SSWDNQCQCT SSATRNTTKQ VTPQPEEQKE RKTTEMQSPM QPVDQASLPG HCREPPPWEN EATERIYHFV VGQMVYYQCV QGYRALHRGP AESVCKMTHG KTRWTQPQLI CTGEMETSQF PGEEKPQASP EGRPESETSC Biological Activity
The ED50 is <1.5 μg/mL as measured by murine CTLL-2 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-2 Receptor alpha, His (HEK293-expressed) (rHuIL-2Rα, His) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-2 Receptor alpha, His (HEK293-expressed) (rHuIL-2Rα, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The cytokine interleukin 2 (IL2) is produced by activated helper T lymphocytes and stimulates proliferation and effector functions of a variety of cells of the immune system. High-affinity IL2 receptors consist of three distinct components, the α chain (IL2Rα, 50-55 kD), the β chain (IL2Rβ, 70-75 kD) and the γ chain[1]. |
