Recombinant Human Interleukin-4 Receptor (HEK293-expressed) 是I型跨膜蛋白，可以结合白细胞介素-4和白细胞介素-13。
Synonyms
rHuIL-4R; IL4R; IL-4RA; CD124 ; 重组人白细胞介素-4受体 (HEK293表达)
Species
HumanSource
HEK 293 Accession
P24394 Gene ID
3566 Molecular Weight
40-45 kDa AA Sequence
GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH Biological Activity
The ED50 is <70 ng/mL as measured by TF-1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-4 Receptor (HEK293-expressed) (rHuIL-4R) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-4 Receptor (HEK293-expressed) (rHuIL-4R) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
The effect of IL-4 signaling is mediated through the IL-4 receptor alpha chain (IL-4Rα). Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells[1]. |
