Recombinant Rat IP-10/CRG-2/CXCL10 (HEK293-expressed) 是具有促炎和抗血管生成特性的CXC趋化因子家族的成员。
Synonyms
rRtIP-10/CRG-2/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1 ; 重组大鼠IP-10/CRG-2/CXCL10 (HEK293表达)
Species
RatSource
HEK 293 Accession
P48973 Gene ID
245920 Molecular Weight
Approximately 8.7 kDa AA Sequence
IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP Biological Activity
The ED50 is <300 ng/mL as measured by CHO-K1/Gα15/rCXCR3 cells (human Gα15 and rat CXCR3 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat IP-10/CRG-2/CXCL10 (HEK293-expressed) (rRtIP-10/CRG-2/CXCL10) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Rat IP-10/CRG-2/CXCL10 (HEK293-expressed) (rRtIP-10/CRG-2/CXCL10) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases[1]. |
