Recombinant Human LD78 beta/CCL3L1是HIV-1共受体CCR5的有效配体，其对于病毒进入人宿主细胞是必需的。
Synonyms
rHuLD78β/CCL3L1; C-C motif chemokine 3-like 1; SCYA3L1 ; 重组人LD78 beta/CCL3L1
Species
HumanSource
E. coli Accession
P16619 Gene ID
6349 Molecular Weight
Approximately 7.8 kDa AA Sequence
APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA Biological Activity
The ED50 is <0.4 μg/mL as measured by CHO cells, corresponding to a specific activity of >2.5 × 103 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human LD78 beta/CCL3L1 (rHuLD78β/CCL3L1) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human LD78 beta/CCL3L1 (rHuLD78β/CCL3L1) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CCL3L1 is the most potent known ligand for CC chemokine receptor 5 (CCR5), the major coreceptor for HIV, and it is a dominant HIV-suppressive chemokine. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility[1]. |
