Recombinant Human MIP-3 alpha/CCL20 是一种 CC 趋化因子配体，受体为 CCR6。
Synonyms
rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20 ; 重组人 MIP-3 alpha/CCL20
Species
HumanSource
E. coli Accession
P78556 Gene ID
6364 Molecular Weight
Approximately 8.0 kDa AA Sequence
ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM Biological Activity
The ED50 is <200 ng/mL as measured by CHO-K1/Gα15/hCXCR6 cells (human Gα15 and human CXCR6 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 53mM Na2HPO4, 147 mM NaH2PO4, 300 mM NaCl, pH 6.5. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human MIP-3 alpha/CCL20 (rHuMIP-3α/CCL20) to 100 µg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human MIP-3 alpha/CCL20 (rHuMIP-3α/CCL20) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CCL20 is a C-C motif chemokine ligand, which has C-C motif Chemokine Receptor 6 (CCR6) as its sole receptor and tissues producing CCL20 recruit CCR6 expressing immune cells[1]. The CCL20/CCR6 axis is also involved in various autoimmune diseases and in other cancers besides HCC[2]. |
