Recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 是 CXC 趋化因子家族成员，能够结合 CXCR4、CXCR7，与肿瘤的增殖、存活、血管生成、转移及免疫抑制有关。
Synonyms
rHuSDF-1α/CXCL12; C-X-C motif chemokine 12; PBSF ; 重组人基质细胞衍生因子-1α/CXCL12
Species
HumanSource
E. coli Accession
P48061 Gene ID
6387 Molecular Weight
Approximately 8.0 kDa AA Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Biological Activity
Full biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20-80 ng/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB pH 7.0, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 (rHuSDF-1α/CXCL12) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Stromal-Cell Derived Factor-1 alpha/CXCL12 (rHuSDF-1α/CXCL12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL12 belongs to the CXC chemokine family, and is expressed in two isoforms, SDF-1α and SDF-1β, binds to CXCR4 and CXCR7. CXCL12/CXCR4 signal is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression[1]. |
