Recombinant Human Tyrosine kinase receptor A (HEK293-expressed) 是神经营养素、神经生长因子的高亲和力催化受体，调节神经生长因子的多种作用，包括神经元分化和避免程序性细胞死亡。
Synonyms
rHuTrkA; NTRK1; MTC; TRK ; 重组人酪氨酸激酶受体 A (HEK293细胞表达)
Species
HumanSource
HEK 293 Accession
P04629 Gene ID
4914 Molecular Weight
65-85 kDa AA Sequence
APCPDACCPH GSSGLRCTRD GALDSLHHLP GAENLTELYI ENQQHLQHLE LRDLRGLGEL RNLTIVKSGL RFVAPDAFHF TPRLSRLNLS FNALESLSWK TVQGLSLQEL VLSGNPLHCS CALRWLQRWE EEGLGGVPEQ KLQCHGQGPL AHMPNASCGV PTLKVQVPNA SVDVGDDVLL RCQVEGRGLE QAGWILTELE QSATVMKSGG LPSLGLTLAN VTSDLNRKNV TC Biological Activity
The ED50 is <1 μg/mL as measured by TF-1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Tyrosine kinase receptor A (HEK293-expressed) (rHuTrkA) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Tyrosine kinase receptor A (HEK293-expressed) (rHuTrkA) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Tyrosine kinase receptor A (TrkA) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. TrkA is originally cloned from a colon tumor; the cancer occurred via a translocation, which results in the activation of the TrkA kinase domain[1][2]. |
