Recombinant Human 4-1BB, Fc Chimera (CHO-expressed) 是在 CHO 中产生的 C-末端标记 IgG1 Fc 片段的多肽链。4-1BB 是肿瘤坏死因子受体超家族的成员。
Synonyms
rHu4-1BB, Fc Chimera; CD137; ILA
Species
HumanSource
CHO Accession
Q07011 Gene ID
3604 Molecular Weight
55-60 kDa AA Sequence
LQDPCSNCPA GTFCDNNRNQ ICSPCPPNSF SSAGGQRTCD ICRQCKGVFR TRKECSSTSN AECDCTPGFH CLGAGCSMCE QDCKQGQELT KKGCKDCCFG TFNDQKRGIC RPWTNCSLDG KSVLVNGTKE RDVVCGPSPA DLSPGASSVT PPAPAREPGH SPQ Biological Activity
Binding ability is measured by immobilized ELISA, 1 µg/mL (100 µL/well) of immoblized recombinant human 4-1BB-Fc Chimera produces 50% optimal binding response approximately 5-15 ng/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human 4-1BB, Fc Chimera (CHO-expressed) (rHu4-1BB, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human 4-1BB, Fc Chimera (CHO-expressed) (rHu4-1BB, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
4-1BB:4-1BBL are a member of the TNFR:TNF ligand family, which are expressed on T cells and antigen-presenting cells (APCs), respectively. Therapies utilizing the 4-1BB:4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. 4-1BB:4-1BBL costimulation has be used for the immunotherapy of cancer[1]. |
