Recombinant Human IFN-gamma Receptor II (CHO-expressed) 是干扰素 γ 受体的其中一个链，可以引起信号转导的发生。
Synonyms
rHuIFN-γ Receptor II; IFNGR2; IFNGT1 ; 重组人 IFN-γ 受体 II (CHO 细胞表达)
Species
HumanSource
CHO Accession
P38484 Gene ID
3460 Molecular Weight
38-40 kDa AA Sequence
SQLPAPQHPK IRLYNAEQVL SWEPVALSNS TRPVVYQVQF KYTDSKWFTA DIMSIGVNCT QITATECDFT AASPSAGFPM DFNVTLRLRA ELGALHSAWV TMPWFQHYRN VTVGPPENIE VTPGEGSLII RFSSPFDIAD TSTAFFCYYV HYWEKGGIQQ VKGPFRSNSI SLDNLKPSRV YCLQVQAQLL WNKSNIFRVG HLSNISCYET MADASTELQQ Biological Activity
The ED50 is <0.1 µg/mL as measured by HT-29 (HTB-38) cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human IFN-gamma Receptor II (CHO-expressed) (rHuIFN-γ Receptor II) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human IFN-gamma Receptor II (CHO-expressed) (rHuIFN-γ Receptor II) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
IFN-γR2 leads to the initiation of the signal transduction events: activation of Jakl and Jak2 receptor associated protein tyrosine kinases, phosphorylation of the IFN-γR1 intracellular domain on Tyr440 followed by phosphorylation and activation of Statlα, the latent transcriptional factor[1]. |
