Recombinant Rat Interleukin-12 (CHO-expressed) 是一种炎性细胞因子，可促进免疫系统反应。
Synonyms
rRtIL-12; CLMF; IL-12A; IL-12B ; 重组大鼠白介素-12 (CHO 细胞表达)
Species
RatSource
CHO Accession
Q9R103; E9PU71 Molecular Weight
26-28 kDa (p35) and 42-45 kDa (p40) AA Sequence
p35: RVIPVSGPAK CLNQSQNLLK TTDDMVRTAR EKLKHYSCTA GDIDHEDITR DKTSTLEACL PLELHKNESC LATKETSSII RGSCLPPQKT SLMMTLCLGS IYEDLKMYQS EFQAINAALQ SHNHQQITLD RNMLMAIDEL MRSLNHSGET LHQKAPMGEA DPYRVKMKLC ILLHAFSTRV MTINRVMNYL SSSHHHHHHp40: MWELEKDVYV VEVDWRPDAP GETVTLTCDS PEEDDITWTS DQRRGVIGSG KTLTITVREF LDAGQYTCHR GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VHRNTDLKFN IKSSSSSPES RAVTCGRASL SAEKVTLNQR DYEKYSVACQ EDVTCPTAEE TLPIELVVEA QQQNKYENYS TSFFIRDIIK PDPPKNLQVK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKTK ETEEECNQKG AFLVEKTSAE VQCKGANICV QAQDRYYNSS CSKWTCVPCR GRS Biological Activity
The ED50 is <0.1 ng/mL as measured by 2D6 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Rat Interleukin-12 (CHO-expressed) (rRtIL-12) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Rat Interleukin-12 (CHO-expressed) (rRtIL-12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-12 is a heterodimeric inflammatory cytokine. Interleukin-12 is a potent cytokine that plays an important role in regulating the response of the adaptive immune system by driving the differentiation of naive T-cells to Th1 cells, which is important for protection against intracellular pathogens[1]. |
