Recombinant Human Macrophage Inflammatory Protein-1 beta/CCL4 (CHO-expressed) 是一种促趋化因子，既能够在各种炎症条件下促进白细胞聚集，又有助于对人类免疫缺陷 1 型病毒产生免疫保护。
Synonyms
rHuMIP-1β/CCL4; MIP-1β; C-C motif chemokine 4; ACT-2; SCYA4 ; 重组人巨噬细胞炎症蛋白-1 β/CCL4 (CHO 表达)
Species
HumanSource
CHO Accession
P13236 Gene ID
388372 Molecular Weight
10-19 kDa AA Sequence
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN Biological Activity
The EC50 is <150 ng/mL as measured on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR5 cells (human Gα15 and human CCR5 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Macrophage Inflammatory Protein-1 beta/CCL4 (CHO-expressed) (rHuMIP-1β/CCL4) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Macrophage Inflammatory Protein-1 beta/CCL4 (CHO-expressed) (rHuMIP-1β/CCL4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Macrophage inflammatory protein-1 (MIP-1β) 1 is a proinflammatory chemokine that both promotes leukocyte accumulation in various inflammatory conditions and contributes to protective immunity against human immunodeficiency virus type 1 (HIV-1) (1-5)[1]. |
