Recombinant Human Proheparin-binding EGF-like Growth Factor (CHO-expressed) 在创伤愈合、心肌肥厚、心脏发育和功能等方面发挥重要作用。
Synonyms
rHuProheparin-binding EGF-like Growth Factor; DTR; DTS; HEGFL ; 重组人促肝素结合EGF样生长因子(CHO表达)
Species
HumanSource
CHO Accession
Q99075 Gene ID
1839 Molecular Weight
12-14 kDa AA Sequence
DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL Biological Activity
The ED50 is <0.5 ng/mL as measured by 3T3 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Proheparin-binding EGF-like Growth Factor (CHO-expressed) (rHuProheparin-binding EGF-like Growth Factor) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Proheparin-binding EGF-like Growth Factor (CHO-expressed) (rHuProheparin-binding EGF-like Growth Factor) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Heparin-binding epidermal growth factor-like growth factor (HBEGF) is a heparin-binding member of the EGF family. It is a potent mitogen and chemotactic factor for fibroblasts and smooth muscle cells. As with other EGF family members, HB-EGF binds and activates EGF receptors 1 and 4. HB-EGF has been shown to stimulate the growth of a variety of cells in an autocrine or paracrine manner and to be involved in stromal proliferation. HB-EGF is also a potent inducer of tumor growth and angiogenesis[1]. |
