Recombinant Mouse Stromal-Cell Derived Factor-1 beta/CXCL12 (CHO-expressed) 是 CXC 趋化因子家族成员，能够结合 CXCR4、CXCR7，与肿瘤的增殖、存活、血管生成、转移及免疫抑制有关。
Synonyms
rMuSDF-1β/CXCL12; SDF-1; PBSF; C-X-C motif chemokine 12; TLSF ; 重组小鼠基质细胞衍生因子-1β/CXCL12 (CHO-expressed)
Species
MouseSource
CHO Accession
P40224 Gene ID
20315 Molecular Weight
Approximately 8.5 kDa AA Sequence
KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM Biological Activity
The EC50 is <2.5 μg/mL as measured on Ca2+ mobilization assay in CHO-K1/Gα15/mCXCR4 cells (human Gα15 and mCXCR4 stably expressed in CHO-K1 cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Stromal-Cell Derived Factor-1 beta/CXCL12 (CHO-expressed) (rMuSDF-1β/CXCL12) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Mouse Stromal-Cell Derived Factor-1 beta/CXCL12 (CHO-expressed) (rMuSDF-1β/CXCL12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL12 belongs to the CXC chemokine family, and is expressed in two isoforms, SDF-1α and SDF-1β, binds to CXCR4 and CXCR7. CXCL12/CXCR4 signal is implicated in tumor proliferation, survival, vascularization, metastasis, and immunosuppression[1]. |
