Recombinant Mouse Angiopoietin-like Protein 3, His (HEK293-expressed) 是在 C 末端带有 10-His 标签的小鼠重组 ANGPTL3，由哺乳动物表达系统产生，并表达编码 Ser17-Thr455 的靶基因。
Synonyms
rMuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3 ; 重组小鼠血管生成素样蛋白 3，His (HEK293 细胞表达)
Species
MouseSource
HEK 293 Accession
Q9R182 Gene ID
30924 Molecular Weight
25-30 kDa AA Sequence
SRVDPDLSSF DSAPSEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LRTNEIKEEE KELRRTTSTL QVKNEEVKNM SVELNSKLES LLEEKTALQH KVRALEEQLT NLILSPAGAQ EHPEVTSLKS FVEQQDNSIR ELLQSVEEQY KQLSQQHMQI KEIEKQLRKT HHHHHH Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Angiopoietin-like Protein 3, His (HEK293-expressed) (rMuAngiopoietin-like Protein 3, His) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Mouse Angiopoietin-like Protein 3, His (HEK293-expressed) (rMuAngiopoietin-like Protein 3, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Angiopoietin-like Protein 3 (ANGPTL3) is a 70 kDa 460-amino acid long secretory glycoprotein primarily expressed in the liver. Mature mouse ANGPTL3 contains an N-terminal coiled-coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is implicated in angiogenesis and atherogenesis. ANGPTL3 can regulate serum lipid levels by acting on lipoprotein lipase- (LPL-) and endothelial lipase- (EL-) mediated triglyceride (TG) and phospholipid hydrolysis. Serum ANGPTL3 levels could serve as a biomarker for future occurrence of major adverse cardiovascular events (MACEs) with coronary artery disease (CAD). ANGPTL3 acts as proangiogenic and could induce angiogenesis in vivo via binding of the C-terminal fibrinogen-like domain to the integrin αvβ3 receptor on vascular endothelial cells[1]. |
