Recombinant Human Angiopoietin-Related Protein 4, His (HEK293-expressed) 通过抑制脂蛋白脂肪酶 (LPL) 调节循环甘油三酯 (TG) 的分布。Angiopoietin-Related Protein 4是一种传统的，非竞争性的LPL 抑制剂。
Synonyms
rHuAngiopoietin-Related Protein 4, His; ANGPTL4; Angiopoietin-Related Protein 4 ; 重组人血管生成素样蛋白4
Species
HumanSource
HEK 293 Accession
Q9BY76 Gene ID
51129 Molecular Weight
32-38 kDa AA Sequence
HHHHHHPEMA QPVDPAHNVS RLHRLPRDCQ ELFQVGERQS GLFEIQPQGS PPFLVNCKMT SDGGWTVIQR RHDGSVDFNR PWEAYKAGFG DPHGEFWLGL EKVHSITGDR NSRLAVQLRD WDGNAELLQF SVHLGGEDTA YSLQLTAPVA GQLGATTVPP SGLSVPFSTW DQDHDLRRDK NCAKSLSGGW WFGTCSHSNL NGQYFRSIPQ QRQKLKKGIF WKTWRGRYYP LQATTMLIQP MAAEAAS Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Angiopoietin-Related Protein 4, His (HEK293-expressed) (rHuAngiopoietin-Related Protein 4, His) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Angiopoietin-Related Protein 4, His (HEK293-expressed) (rHuAngiopoietin-Related Protein 4, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Angiopoietin-like proteins (ANGPTLs) represent a family of eight secreted glycoproteins that show structural homology to angiopoietins and carry distinct physiological functions, including putative roles in lipid metabolism, expansion of stem cells, inflammation, tissue remodeling and angiogenesis. In recent years, three ANGPTLs, ANGPTL3, ANGPTL4 and ANGP-TL8, have been shown to play a role in lipid metabolism and in the regulation of plasma lipid levels. ANGPTL4 and ANGPTL8 form a complex when refolded together and that ANGPTL4 in that complex loses its ability to inactivate LPL. Angiopoietin-like protein 4 (ANGPTL4) is a secreted 50 kD protein that modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). ANGPTL4 is a positive acute phase protein and its increase could contribute to the hypertriglyceridemia that characteristically occurs during the acute phase response by inhibiting LPL activity. |
