Recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) 调控血管生成，通过Wnt信号通路促进人造血干细胞和祖细胞的增殖。Angiopoietin-related Protein 7是一种促炎因子，通过P38 MAPK信号通路诱导巨噬细胞的炎症反应。
Synonyms
rHuAngiopoietin-related Protein 7, His; ANGPTL7; Angiopoietin-related Protein 7 ; 重组人血管生成素样蛋白7
Species
HumanSource
HEK 293 Accession
O43827 Gene ID
10218 Molecular Weight
45-55 kDa AA Sequence
QKLSKHKTPA QPQLKAANCC EEVKELKAQV ANLSSLLSEL NKKQERDWVS VVMQVMELES NSKRMESRLT DAESKYSEMN NQIDIMQLQA AQTVTQTSAD AIYDCSSLYQ KNYRISGVYK LPPDDFLGSP ELEVFCDMET SGGGWTIIQR RKSGLVSFYR DWKQYKQGFG SIRGDFWLGN EHIHRLSRQP TRLRVEMEDW EGNLRYAEYS HFVLGNELNS YRLFLGNYTG NVGNDALQYH NNTAFSTKDK DNDNCLDKCA QLRKGGYWYN CCTDSNLNGV YYRLGEHNKH LDGITWYGWH GSTYSLKRVE MKIRPEDFKP HHHHHHHHHH Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) (rHuAngiopoietin-related Protein 7, His) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) (rHuAngiopoietin-related Protein 7, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human Angiopoietin-related Protein 7 is the least explored member of the Angptl family. It was originally cloned from human corneal cells and named corneaderived transcript 6. Angiopoietin-related Protein 7 can modify the expression of extracellular matrix proteins in human melanoma cells and trabecular meshwork cells, indicating that it functions as a corneal morphogen and can regulate intraocular pressure. |
